- In the clubs' most recent two-legged knockout tie, Valencia defeated Atletico in the 2007/08 Spanish Cup quarter-finals on away goals. They eventually won the competition that season.
- Valencia have won all four of their previous two-legged European ties against Spanish opposition in Europe.
- Valencia have picked up 33 yellow cards and four red cards in the Europa League this season, the worst disciplinary record of any side in the competition since the group stages.
- Valencia have not won in nine successive away matches in all competitions.
- Atletico have won six of their last eight games at home in all competitions, drawing the other two.
- Diego Forlan has scored in each of his last five appearances for Atletico.
- David Villa has scored seven goals in his last five appearances for Valencia.
