Wolves have won their last two games at Molineux and would have given local rivals West Brom a tough game had last week's fixture at the Hawthorns gone ahead.
A win for the Midlands side on Sunday could see them escape the bottom three for the first time since the beginning of the season.
Hitting Rock Bottom?
Wigan, meanwhile, are in a spot of bother having not won since mid-November, and have not won away since August, when the Latics triumphed by a slender margin at White Hart Lane.
Defeat for the Lancashire would see them slip behind their opponents in the league table and would see the odds on Wigan falling down to the Championship tumble even further after a mixed season.
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Wolverhampton Wanderers
Boss Mick McCarthy will be without long-term absentees Karl Henry, Jody Craddock and Adlene Guedioura, who are all not due back until late January at the earliest.
Kevin Doyle will also undergo a late fitness test to ascertain whether he will be able to start, with Sylvan Ebanks-Blake primed to start up top if the Irishman is ruled out.
But the home side, despite being rooted to the bottom of the Premier League disciplinary table, otherwise have a full host of players to choose from with no suspensions.
Possible starting XI: Hahnemann; Zubar, Stearman, Berra, Elokobi; Jarvis, Foley, Mancienne, Milijas, Hunt; Ebanks-Blake
Wigan Athletic
The Honduran duo of Maynor Figueroa and Hendry Thomas will both be missing through suspension after picking up a host of yellow cards this season, leaving manager Roberto Martinez with something of a selection headache.
James McCarthy, Victor Moses and Franco di Santo are all expected to miss out through injury.
Possible starting XI: Habsi; Stam, Gohouri, S Caldwell, Alcaraz; Cleverley, McArthur, Watson, Diame, N'Zogbia; Rodallega
Prediction
A six pointer if ever there was one for these sides, who will both eye the scrap with a fellow struggler as an opportunity to pick up much needed points to ward away from relegation.
The Latics won 2-0 at Molineux last season, but will struggle without the power of Figueroa and Thomas, and Wolves should have enough to grab at least a point.
The Latics won 2-0 at Molineux last season, but will struggle without the power of Figueroa and Thomas, and Wolves should have enough to grab at least a point.
Wolves 1-1 Wigan Athletic 
