AC Milan v Tottenham Hotspur
* Zlatan Ibrahimovic has scored four goals in five Champions League starts for Milan.
* Spurs have already played once at the San Siro this season, losing 4-3 to Inter in the Group Stage.
* Spurs and Milan met in the 1971-72 UEFA Cup semi-final where Tottenham won the home leg and drew away to progress to the final.
* Tottenham have scored a joint-competition-high 18 goals in the Champions League this season.
* Harry Redknapp's side scored with 28% of their goal attempts, the best percentage in the competition.
* Milan have the worst disciplinary record in the Champions League picking up 17 Yellow Cards.
* Milan drew the first two, won the next pair and have lost the last two home matches in the Champions League against English opposition.
* Milan have won none of their last five matches in European competition against English opposition.
* Peter Crouch has scored three goals from just five shots on target in the Champions League this season.
* Spurs have lost two and drawn one of their three trips to Italy in European competition.
* Milan have been knocked out at this stage by an English team in the last two seasons.
Valencia v Schalke 04
* Valencia have played Schalke four times in European competition, drawing both of the home games at the Mestalla.
* Valencia have drawn seven of the last 10 matches played against German opposition including the last three in a row.
* Valencia have only won four of their last 17 Champions League matches.
* The Spaniards have only won one of their last 12 European games against German opponents, but that was a 1-0 away victory against Schalke in the 2007-08 Champions League.
* Schalke have not won any of their last seven European games against Spanish opposition, failing to score in six of those matches.
* Schalke have only conceded seven goals in their last 13 Champions League matches and not more than one in any of those fixtures.
* Schalke have scored 14, but failed to score in eight of their last 14 Champions League games.
* Schalke had failed to score in their previous six Champions League away games prior to beating Benfica in their last away match of the Group Stage.
* Valencia have not beaten any of the three German sides to visit the Mestalla in the Champions League.
* Only three teams scored more goals than Valencia (15) in the Group Stage.
AS Roma v Shakhtar Donetsk
* Shakhtar won 103 fouls in the Group Stage, more than any other team.
* Roma are the only one of the teams qualified for the Last 16 who have not kept a clean sheet in the Champions League this season.
* Eduardo has scored three goals from just six shots in the competition so far.
* Six of the seven shots attempted by Luiz Adriano have been on target and three have resulted in goals.
* Roma have won five of their last six Champions League home matches.
* Shakhtar have only scored in one half of each of their six matches in the Champions League this season.
* Roma were drawn against Shakhtar in the 2006-07 Champions League Group Stage, winning at home and losing away.
* Roma have won three and lost three of their six Champions League games against Ukrainian teams, failing to score in all three defeats.
* Shakhtar have won only two and lost 10 of their 12 matches in European against Italian teams, but one of those was against Roma.
* Shakhtar have lost all six away European games in Italy, conceding four or more in each of the last four.
* Marco Borriello has scored in four of his last five Champions League appearances.
Arsenal v Barcelona
* Arsenal have scored a joint-competition-high 18 goals in the Champions League this season.
* Arsenal and Barcelona have been drawn together three times in Europe, the 1999-2000 Group Stage, the 2006 final and last season's quarter final, with Arsenal winning none and losing three of the five games.
* There have been red cards in three of the five matches between Barcelona and Arsenal.
* No team from continental Europe has won away at Arsenal in the Champions League since Inter beat the Gunners 3-0 in September 2003 - a run of 36 games with the only defeats coming against English sides (Chelsea and Manchester Utd).
* Only two teams (Barcelona and Manchester United have scored more than once in 33 Champions League games at the Emirates, with 21 sides failing to score at all.
* Arsenal have won penalties in eight of their last 11 Champions league games at the Emirates Stadium and each of their last five.
* Arsenal have kept just one clean sheet in their last eight Champions League games.
* Lionel Messi has scored 13 goals in his last 11 Champions League starts including four in one game against Arsenal.
* Arsenal hit the target with 63% of their shots in the Group Stage, the highest percentage in the competition.
* Barcelona had the tightest defence in the group stage, allowing their opponents just eight shots on target against them.
* Marouane Chamakh has scored three goals from just six shots in Europe this season.
* Barcelona have made the semi-finals of the Champions League in the last three seasons.
FC København v Chelsea
* Nicolas Anelka has scored five goals from just seven shots on target in the Champions League this season.
* Anelka has scored eight times in his last 10 Champions League starts.
* FC København posted the worst shooting accuracy figures of any of the teams who qualified for the Last 16, hitting the target with just 29% of their shots.
* The Danish side met Chelsea in the 1998-99 Cup Winners Cup, drawing at Stamford Bridge and then losing 0-1 at home.
* Chelsea have only won two of their last 15 Champions League away games in the knockout stages.
* Chelsea have kept just two clean sheets in their last 11 Champions League games in the knockout phase.
* FC København have won four and drawn two of their six Champions League home games.
* FC København have only won one of their six European matches against English opposition.
* Chelsea have drawn Danish opposition twice winning three games and losing none of the four legs.
* Three of København's seven goals in the Champions League so far have come from shots from outside the box.
Olympique Lyonnais v Real Madrid
* Real Madrid fired in 52 shots on target, more than any other team in the Group Stage.
* Lyon were caught offside 30 times in the Group Stage, more often than any other team.
* Xabi Alonso created 19 goalscoring chances for his team-mates, more than any other player in the Champions League this season.
* Real Madrid fired in 107 attempts (excluding blocked efforts) in the group stage, more than any other team, though Lyon fired in the second-highest tally of 88.
* Lyon and Real have been drawn against each other three times in the Champions League, with the French side winning all three home games and drawing all three at the Bernabeu.
* Real Madrid have not scored in any of their three previous trips to Stade Garland.
* Cristiano Ronaldo has fired in 16 shots on target, more than any other player in this season's Champions League.
* Karim Benzema has scored 16 goals in 23 Champions League starts for Real Madrid and previous club Lyon.
* Only Manchester United (1) have conceded fewer goals than Real Madrid in this season's Champions League.
* Real have lost just one of their last 11 Champions League matches, but that was away at Lyon.
* Real Madrid have been knocked out at this stage in each of the last six campaigns, including by Lyon last season.
* However, the last time they made it to the quarter-finals was also the last time before this season that they went unbeaten in the group stages (2003/04).
Marseille v Manchester United
* Manchester United have the worst conversion rate of all the teams who have made the Last 16 of the Champions League scoring with just 10% of their chances.
* United have lost just one of their last 20 Champions League away games, winning nine of the last 10.
* Sir Alex Ferguson's side have the best defensive record in the competition having conceded just one goal in the Group Stage.
* Marseille have kept clean sheets in their last four Champions league matches.
* Marseille have played English opposition 10 times in the Champions league and all four of their wins have been 1-0 successes.
* Marseille have only scored six goals in their 10 Champions League games against English opposition and never more than once in a match.
* United and Marseille drew each other in the 1999-2000 1st Group Stage with both sides winning their home games by a single-goal margin.
* Man Utd had fewer players shown cards in the Group Stage (3) than any other team.
* United have only lost two of their 24 European matches against French opposition.
* Only one French team (Lyon in 2004) has ever scored more than one goal against Man Utd in European competition.
Internazionale v Bayern München
* Samuel Eto'o has scored seven goals from just 10 shots on target in the Champions League.
* Mario Gomez has scored six goals from just eight shots on target.
* Inter met Bayern in the 2010 Champions League final, with the Italian side winning 2-0.
* Bayern have won both of their European matches against Inter at the San Siro.
* The five meetings between Bayern and Inter have seen two wins apiece, one draw and both sides scoring six goals in total.
* Inter are unbeaten in their last 10 Champions League games at San Siro, winning the last seven in a row.
* Inter have only won two of their last eight Champions League matches against German opposition.
* Bayern have won seven and lost two of their last nine Champions League games, but the two defeats were against Italian sides.
* Bayern have only won two out of 10 Champions league away games against Italian sides.
* Only Arsenal and Tottenham Hotspur scored more goals than Bayern in the Group Stage.
* Bayern's last three Champions League defeats away from home have all been by a 2-3 scoreline.
