* Once Caldas are on form in South America and Colombia, currently on top in the Apertura.
* The Manizales club have won the Libertadores once before, in 2004.
* Remarkably, five players remain from that team: Henao, Henriquez, Valentierra, Amaya and Moreno .
* The team qualified with the worst record in the last 16, gaining only 7 points in the group stage.
* They made up for it in the second round, beating Cruzeiro 3-2 on aggregate with a great 2-0 win in Belo Horizonte.
* Santos meanwhile gained a 1-0 aggregate victory over America to make the quarters.
* Like Wednesday's rivals, they had to wait until the final round of group stage fixtures to make sure of their passage.
* The Brazilians finished second in Group 5 behind Cerro Porteno, with 11 points.
* They boast two Copa Libertadores crowns, although the last was achieved back in 1963.
* Overall the Peixe have made the Libertadores 10 times in their history, winning 50 out of 86 games. Only Cruzeiro can boast a better winning percentage in games from the teams who have competed more than 10 times.
PROBABLE LINE-UPS
Once Caldas (4-4-2)
Martinez; Palacios, Amaya, Henriquez, Luis Nunez; Henao, Mejia, Pajoy, Micolta; Moreno, Renteria
Yedinson Palacios comes in at the back for Elkin Calle while John Pajoy and Felix Micolta are new faces in the middle, as Caldas make three changes from the team that downed Cruzeiro.
Santos (4-4-2)
Rafael; Jonathan, Dracena, Durval, Leo; Adriano, Danilo, Elano, Possebon; Neymar, Ze Eduardo
Ganso suffered a thigh injury at the weekend and is the big absence for Santos; Rodrigo Possebon enters for the 21-year-old as the Peixe are otherwise at full-strength.
Prediction
Once Caldas 1-1 Santos 
