Spain (4-3-3):
Casillas; Arbeloa, Ramos, Raul Albiol, Dominguez; Xabi Alonso, Xavi, Iniesta; Villa, Torres, Mata
Del Bosque may experiment with his side and there may be starts for Chelsea duo Fernando Torres and Juan Mata with the world champions having cancelled a tie against Brazil in favour of this contest against their South American counterparts.
Spain have included three uncapped players in their squad to face Chile, in the shape of Alvaro Dominguez, Sporting Gijon centre-back Alberto Botia and Barcelona B right-back Martin Montoya, with Vicente del Bosque leaving out veteran defenders Carlos Marchena and Joan Capdevilla as a result.
Barcelona defenders, Carles Puyol and Gerard Pique are out due to injury, along with full-back Andoni Iraola, whilst Nacho Monreal misses out after being named in the squad to play Italy.
Chile (3-5-2):
Bravo; Contreras, Jara, Vidal; Cermona, Beausejour, Medel, Isla, Valdivia; Alexis Sanchez, Orellana
Claudio Borghi will be without defender Waldo Ponce who withdrew from the squad due to injury, as have Matias Fernandez (leg) and Mauricio Pinalla (knee). Mark Gonzalez will also miss the fixture against the World Cup winners in Switzerland due to the same hip injury which kept the CSKA Moscow man out of the Copa America.
Felipe Seymour, who missed the Copa America, is back in contention and is likely to be named on the bench, after recovering from a long-term injury.
Gustavo Canales could make his debut for Chile after receiving a call-up for the match against Spain, whilst Borghi also included uncapped Gerson Acevedo and Christian Vilches.
Barcelona’s summer signing Alexis Sanchez is included in the squad, and at the tender of age of 22 represents Chile's main threat with an impressive international record of 14 goals in 41 appearances.
DID YOU KNOW?
Spain have never lost to Chile in any of their eight fixture; the Europeans have won seven of those matches, and drawn once.
13 players named in the Spain squad to play Chile are from one of Barcelona or Real Madrid, the ratio 8:5 in the Catalans' favour.
Spain have dropped to 2nd in the Fifa World Rankings after their defeat to Italy saw Vincent Del Bosque’s fall behind the World Cup finalists Holland.
A David Villa hat-trick would see him become the first Spaniard to reach 50 goals in international colours.
Chile are unbeaten in international friendly matches since the turn of the year; beating Colombia and Estonia, and drawing against the USA, Portugal, Paraguay and France.
During the Copa America, Chile managed a draw against eventual winners Uruguay in the group stages but were beaten, surprisingly, by Venezuela in the quarter-finals.
It took Chile until their 34th international to register a victory. They made up for lost time, though, with a 7-1 win over Bolivia in 1926.
Chile faced Spain in the 2010 World Cup group stages, with Marcelo Bielsa's side beaten 2-1 in Pretoria after goals from David Villa and Andres Iniesta.
Prediction
The World Champions are going to have too much for the Chileans in Switzerland but the threat of Alexis Sanchez may make for an interesting finish to the game.
Editor's Prediction
Spain 2-1 Chile 
