If either team were to win this game it would make them odds-on favourites to qualify for the knockout stages in second place, behind group leaders Manchester United.
In their previous game at Ibrox twelve days ago, these two sides played out a 1-1 draw thanks to Rangers’ Maurice Edu netting at both ends.
Pain in Spain
Despite competing in European competitions in more seasons than any other British club, Rangers have beaten Spanish opposition just three times.
The Scottish champions will be looking for a positive result as they aim to qualify for the knockout stages for the first time since 2005/06.
Looking to end miserable run
Despite being the early pace-setters in La Liga, which led to hopes of a sustained title challenge alongside Barcelona and Real Madrid, just one point from their last three games has seen Valencia them slip down to fourth.
Unai Emery will be hoping that a win against Rangers will help his side recapture their early-season form.
TEAM NEWS
Valencia
The biggest decision manager Unai Emery will have to make before naming his Valencia side will be over who to play in goal.Regular ‘keeper Cesar Snachez has missed his sides last three league games with a minor injury, meaning Miguel Angel Moya has been deputising.
However, Sanchez has been back training and his greater experience may be relied upon for this important match.
Possible starting XI: Sanchez; Miguel, Navarro, Costa, Mathieu; Pablo, Banega, Mata, Topal, Vincente; Aduriz
Rangers
Despite travelling to Spain with the rest of the Rangers squad, midfielders Maurice Edu and Vladimir Weiss are both injury doubts for game.Edu has rated his chances at just 50-50 to participate in the game, whilst Weiss will be a worry for manager Walter Smith after he was taken off with a heel problem at halftime against Inverness Caledonian Thistle on Saturday.
However, Naismith and Whittaker should return after being rested on the bench at the weekend.
Rangers should continue with their five-man midfield behind the lone Kenny Miller in attack, which they have favoured in Europe this season.
Possible starting XI: McGregor; Broadfoot, Bougherra, Weir, Papac, Whittaker; Naismith, Davis, Edu, Weiss; Miller
Prediction
It will not be pretty as Rangers will come to stifle their opposition. A repeat of the superb rearguard action that saw them earn a draw against Manchester United in the opening group game would be a huge boost to their chances of qualifying for the knockout stages.
Valencia 0-0 Rangers 
