Germany will play their first ever international at the Rhein-Neckar Arena in Sinsheim, which is normally home to Bundesliga outfit Hoffenheim, whose village is too small to house such a stadium.
Coach Joachim Low has called up Borussia Monchengladbach's Marco Reus for the first time and, should the in-form attacker shake off injury, he could make his debut off the bench.
Miroslav Klose has 61 international goals, seven behind Gerd Mueller's record. Should he appear, the Bayern man will break Jurgen Klinsmann's record of 108 international caps.
Die Mannschaft have a perfect record in Euro 2012 qualifying, having won all five of their matches in a group containing Turkey, Belgium, Austria, Azerbaijan and Kazakhstan.
Although this will be their third friendly against the South Americans, they have only met each other once in a competitive fixture - in last summer's World Cup.
Uruguay finished in fourth place at the World Cup after passing France, Mexico and South Africa in Group A, and then South Korea and Ghana in the knockout stages.
Their semi-final berth represented their best performance in a World Cup finals tournament since 1970, when they also made the last four.
Uruguay's total population of 3.4 million is around the same as that of Germany's capital Berlin alone.
They have lost on each of the three occasions they have met a unified German team, scoring just three goals in reply to Germany's 12.
Their record is little better against both West and East Germany, winning just one of 12 encounters, that back in January 1985 when they defeated East Germany 3-0 in Montevideo.
LAST MEETING
July 10, 2010: Uruguay 2-3 Germany
Thomas Muller gave the favourites the lead after 19 minutes before the surprise package of the World Cup hit back with goals from Edinson Cavani before the half-hour and Diego Forlan on 51 minutes, capping a superb tournament for the Atletico Madrid hitman. However, Joachim Low's men secured a deserved third spot thanks to Marcell Jansen's equaliser on 56 minutes and Sami Khedira's winner eight minutes from the end of normal time.
PROBABLE LINE-UPS
Germany:
Neuer; Lahm, Friedrich, Hummels, Schmelzer; Trasch, Rolfes; Schurrle, Ozil, Podolski; Klose
Uruguay:
Muslera; Maxi Pereira, Diego Lugano, Godin, Caceres; Perez, Arevalo Rios, Alvaro Pereira; Forlan; Suarez, Cavani
Prediction
Germany 3-1 Uruguay 
