Valencia (4-2-3-1):
Guaita; Bruno, Rami, Costa, Alba; Topal, Banega; Hernandez, Piatti, Canales; Soldado
Pablo Hernandez will be looked upon to provide quality opportunities to Roberto Soldado. Pablo Piatti, who joined the team from Almeria over the summer, will again be the central attacking midfielder, looking to test the goalkeeper more than in the team's first league game.
Atletico Madrid (4-4-2):
Courtois; Silvio, Perea, Dominguez, Luis; Reyes, Thiago, Gabi, Suarez; Adrian, Falcao.
Radamel Falcao will make his highly anticipated debut in red and white, joining Jose Antonio Reyes and Adrian Lopez in the attack. Diego looks set to be on the bench to start the encounter.
DID YOU KNOW?
Valencia opened their league campaign with a 4-3 victory over Racing Santander.
In the win, Soldado scored a hat-trick, including two goals in the dying minutes to earn the Champions League side all three points.
Soldado is a Real Madrid product but was actually born in Valencia.
Unai Emery's men took four points from two games against Atletico last season.
Atletico Madrid failed to find the net in their first game of the league season, drawing 0-0 with Osasuna.
Falcao, who joined Gregorio Manzano's men in the summer from Porto, scored 73 goals in 81 games for the Portuguese club over two seasons.
Another former Porto star, Brazil's Diego, joined the club on a season-long loan on the last day of the transfer window.
After finishing in fourth place in the 2008-09 campaign to earn Champions League qualification, the nine-time La Liga winners finished ninth in 2009-10 before finishing seventh last season.
Prediction
At home, the scoring talent of Roberto Soldado should be too much for the Atletico defence.
Editor's Prediction
Valencia 2-1 Atletico Madrid