Velez Sarsfield must win in the Jose Almafitani tonight to have any chance of making the final for the second time.
1-0 down, the onus will be on strike duo Juan Manuel Martinez (right) and Santiago Silva to hit home: the pair have already hit six between them in the competition so far.
The club's last visit to the last four was in 1994, where they beat Colombians Junior on the way to lifting the title.
Coach Ricardo Gareca has an unfortunate relationship with the Libertadores; having lost three consecutive finals with America de Cali between 1985-87.
The 1987 final was against none other than tonight's opponents, with coach Diego Aguirre up front.
Penarol are also looking to cut short a long dry spell in the Copa, 1987 being the last time they reached the final.
This is their record 14th appearance in the semi-finals, more than any other team.
Of their previous 13 appearances, they have gone on to the final nine times, registering five titles and four defeats in the decider.
The Manya have played away in every Libertadores second-leg this year, with one victory (vs. Internacional) and one defeat (vs. Universidad Catolica).
The side have scored just 13 times in 11 games on their way to this match, just over half the amount scored by their Argentine rivals (24).
PROBABLE LINE-UPS
Velez Sarsfield (4-3-1-2):
Barovero; Cubero, DomÃnguez, Ortiz, Papa; Fernandez, Razzotti, Zapata; Moralez; Silva, MartÃnez
After the last-minute withdrawal of Moralez last week, Velez are boosted by the return of their top scorer for this crucial encounter.
Penarol (4-4-2):
Sosa; G. Rodriguez, D. Rodriguez, Gonzalez, Valdez; Aguiar, Freitas, Corujo, Mier; Olivera, Martinuccio
Striker Diego Alonso is the only forced absence for Diego Aguirre, who has the luxury of picking an unchanged team from the first leg.
Prediction
Velez Sarsfield 3-1 Penarol
