Austria are three points behind Belgium, but have a game in hand as they try to secure a spot as runners-up in Group A.
The hosts will be very familiar with their opponents: five players in their squad play in the German Bundesliga.
Constantini's men have lost their last two matches, prompting a shuffling of the squad ahead of their showdown with Germany.
Young midfielder and full-back Daniel Royer has been promoted from the under-21 team and could make his first senior cap on Friday.
The last time Austria faced Germany was at Euro 2008, on home soil. The final score read 1-0 to the visitors.
Germany have a perfect 15 points from five Euro 2012 qualifiers.
Die Mannschaft could book their spot at Euro 2012 with victories over Austria and Azerbaijan in their next two matches.
Alongside the Netherlands, Low's squad boasts Europe's best goal difference in qualifiers, with the second-highest goals scored tally, and joint-best defensive record.
The last time Germany failed to qualify for a major tournament was in 1968, when they missed out on the European Championships.
Mario Gomez has scored in his last two international matches.
PROBABLE LINE-UPS
Austria (4-2-3-1)
Berger; Dragovic, Prodl, Pogatetz, Fuchs; Pehlivan, Bumgartlinger; Harnik, Juzonovic, Alaba; Janko
The most glaring omission from Didi Constantini's squad is Marko Arnautovic, who after some poor performances - and questionable behaviour - has been dropped. Andreas Ivanschitz has also failed to earn a call. The upcoming matches allow Constantini to experiment with his squad, which includes four uncapped players. Among them is Hans-Peter Berger, who will deputise for injured goalkeeper Jurgen Macho.
Constantini is unlikely to be overly aggressive and will likely start Marc Janko as a lone striker, meaning that Stefan Maierhofer, who only recently recovered from a metatarsal injury, will be relegated to the bench.
Germany (4-2-3-1)
Neuer; Lahm, Friedrich, Hummels, Schmelzer; Khedira, Kroos; Muller, Ozil, Podolski; Gomez
Germany have suffered a blight of injuries in recent weeks, with Miroslav Klose and Christian Trasch the most recent candidates to drop out of Joachim Low's squad. In addition, Marco Reus, Bastian Schweinsteiger and Sven Bender have been forced to withdraw, meaning that the coach will have a headache as he selects his defensive midfield pairing.
Sami Khedira may start after recovering from a hamstring problem, but Simon Rolfes remains an option in defensive midfield alongside Toni Kroos. In place of Klose, Mario Gomez will get the nod.
Prediction
Austria always bring their best game when facing their neighbours, and Friday's match should be no different. When these teams met at Euro 2008, only a Michael Ballack free kick separated the two teams. In this case, the visitors will have a better, if less experienced, team that ought to be able to grind out another victory.
Austria 0-1 Germany 
